Lithium Chloride → HCID 66995735, compound

HRID 1675612Notes

Reaction equation

HRID 1675612 reaction equation
C([O:5][C:6](=[O:19])[CH2:7][O:8][C:9]1[CH:14]=[C:13]([F:15])[C:12]([F:16])=[CH:11][C:10]=1[O:17]C)(C)(C)C.[Cl-].[Li+]>CN(C=O)C>[F:16][C:12]1[C:13]([F:15])=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:19])=[O:5])=[C:10]([OH:17])[CH:11]=1

Participants

4

Reactant 2

HCID 433294Lithium ChlorideHCID 86034419HCID 86034419, compound

Product 1

HCID 66995735HCID 66995735, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
150 °C

Procedure

A mixture of the product from step (ii) (0.75 g) and lithium chloride (0.345 g) in DMF (20 ml) was heated at 150° C. for 6 h, cooled and partitioned between ethylacetate/2M hydrochloric acid. The organics were dried and evaporated under reduced pressure, yield 0.7 g.

Workup

  1. temperaturecooled
  2. custompartitioned between ethylacetate/2M hydrochloric acid
  3. customThe organics were dried
  4. customevaporated under reduced pressure, yield 0.7 g

Sources & evidence

ORD record
ord-4a279a4ca66849e89f9dd5d0407999b9
Source dataset
uspto-grants-2011_08
Patent number
US08003703B2

Reaction notes

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