Potassium Carbonate → HCID 86659308, compound

HRID 1675622Notes

Reaction equation

HRID 1675622 reaction equation
C(=O)([O-])[O-].[K+].[K+].[CH3:7][O:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[OH:16].[C:17]([O:21][C:22](=[O:27])[C:23](Br)([CH3:25])[CH3:24])([CH3:20])([CH3:19])[CH3:18]>C(#N)C.O>[F:15][C:13]1[CH:12]=[CH:11][C:10]([O:16][C:23]([CH3:25])([CH3:24])[C:22]([O:21][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:27])=[C:9]([O:8][CH3:7])[CH:14]=1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 90290tert-Butyl 2-bromo-2-methylpropionateHCID 27373684-Fluoro-2-methoxyphenol

Product 1

HCID 86659308HCID 86659308, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Procedure

Potassium carbonate (0.97 g) was added to a solution of 2-methoxy-4-fluorophenol (1.0 g) and tert-butyl-2-bromoisobutyrate (1.31 ml) in acetonitrile (20 ml) and heated under reflux for 26 h. The mixture was diluted with water and extracted with ethyl acetate, the organics were dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with using isohexane:diethylether 3:1, yield 0.83 g.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 26 h
  3. extractionextracted with ethyl acetate
  4. customthe organics were dried
  5. customevaporated under reduced pressure
  6. customThe residue was purified by chromatography on silica eluting with using isohexane:diethylether 3:1, yield 0.83 g

Sources & evidence

ORD record
ord-066be09663174d1fb33205049732e17c
Source dataset
uspto-grants-2011_08
Patent number
US08003703B2

Reaction notes

Loading…