HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 66995623, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Chloro-1-fluoro-4-nitrobenzene | HCID 67688 | — |
| Reactant | 5-fluoro-2-methoxyphenol | HCID 2774559 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 66995623 | HCID 66995623 | — |
Reaction Steps
Sodium hydride (60% disp. oil, 0.281 g) was added to a solution of 5-fluoro-2-methoxyphenol (11.0 g) in DMF (20 ml) and stirred at RT for 30 min. 2-Chloro-1-fluoro-4-nitrobenzene (1.23 g) was added and the mixture stirred at RT for 16 h then diluted with water and extracted with diethylether. The organics were dried and evaporated under reduced pressure, yield 1.95 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003703B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-5329f05bb40f46c4aeb75c6d69c67481 |
| Source note | uspto-grants-2011_08 |