Sodium hydride → HCID 66995623, compound

HRID 1675627Notes

Reaction equation

HRID 1675627 reaction equation
[H-].[Na+].[F:3][C:4]1[CH:5]=[CH:6][C:7]([O:11][CH3:12])=[C:8]([OH:10])[CH:9]=1.[Cl:13][C:14]1[CH:19]=[C:18]([N+:20]([O-:22])=[O:21])[CH:17]=[CH:16][C:15]=1F>CN(C=O)C.O>[Cl:13][C:14]1[CH:19]=[C:18]([N+:20]([O-:22])=[O:21])[CH:17]=[CH:16][C:15]=1[O:10][C:8]1[CH:9]=[C:4]([F:3])[CH:5]=[CH:6][C:7]=1[O:11][CH3:12]

Participants

6

Reactant 3

HCID 24758Sodium hydrideHCID 676882-Chloro-1-fluoro-4-nitrobenzeneHCID 27745595-fluoro-2-methoxyphenol

Product 1

HCID 66995623HCID 66995623, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

Sodium hydride (60% disp. oil, 0.281 g) was added to a solution of 5-fluoro-2-methoxyphenol (11.0 g) in DMF (20 ml) and stirred at RT for 30 min. 2-Chloro-1-fluoro-4-nitrobenzene (1.23 g) was added and the mixture stirred at RT for 16 h then diluted with water and extracted with diethylether. The organics were dried and evaporated under reduced pressure, yield 1.95 g.

Workup

  1. stirringthe mixture stirred at RT for 16 h
  2. extractionextracted with diethylether
  3. customThe organics were dried
  4. customevaporated under reduced pressure, yield 1.95 g

Sources & evidence

ORD record
ord-5329f05bb40f46c4aeb75c6d69c67481
Source dataset
uspto-grants-2011_08
Patent number
US08003703B2

Reaction notes

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