HCID 66995623, compound → HCID 66996064, compound

HRID 1675628Notes

Reaction equation

HRID 1675628 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[O:11][C:12]1[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:13]=1[O:19][CH3:20]>C(O)(=O)C.[Fe]>[Cl:1][C:2]1[CH:7]=[C:6]([CH:5]=[CH:4][C:3]=1[O:11][C:12]1[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:13]=1[O:19][CH3:20])[NH2:8]

Participants

4

Reactant 1

HCID 66995623HCID 66995623, compound

Product 1

HCID 66996064HCID 66996064, compound

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 176Acetic AcidSolvent

Procedure

Iron powder (2.0 g) was added to a solution of the product from step (i) (1.95 g) in acetic acid (40 ml) and the mixture stirred at RT overnight. The mixture was filtered and the filtrate evaporated under reduced pressure. The residue was partitioned between aqueous sodium hydrogencarbonate soln and ethylacetate, the organics dried and evaporated under reduced pressure.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate evaporated under reduced pressure
  3. customThe residue was partitioned between aqueous sodium hydrogencarbonate soln
  4. dry with materialethylacetate, the organics dried
  5. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-914845aa11b4499a9de0993d85458e4c
Source dataset
uspto-grants-2011_08
Patent number
US08003703B2

Reaction notes

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