Ethanesulfonyl chloride → HCID 11153919, compound

HRID 1675629Notes

Reaction equation

HRID 1675629 reaction equation
[CH2:1]([S:3](Cl)(=[O:5])=[O:4])[CH3:2].[NH2:7][C:8]1[CH:30]=[CH:29][C:11]([O:12][C:13]2[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:14]=2[O:15][CH2:16][C:17]([O:19]C(C)(C)C)=[O:18])=[C:10]([Cl:31])[CH:9]=1>N1C=CC=CC=1>[Cl:31][C:10]1[CH:9]=[C:8]([NH:7][S:3]([CH2:1][CH3:2])(=[O:5])=[O:4])[CH:30]=[CH:29][C:11]=1[O:12][C:13]1[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:14]=1[O:15][CH2:16][C:17]([OH:19])=[O:18]

Participants

4

Reactant 2

HCID 11667Ethanesulfonyl chlorideHCID 86659309HCID 86659309, compound

Product 1

HCID 11153919HCID 11153919, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Ethane sulphonyl chloride (0.05 ml) was added to a solution of the product from step (iv) (0.19 g) in pyridine (10 ml) and stirred at RT for 2 h. The solvent was evaporated under reduced pressure and the residue dissolved in DCM (10 ml) and trifluoroacetic acid (10 ml).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. dissolutionthe residue dissolved in DCM (10 ml)

Sources & evidence

ORD record
ord-5f7282fc58034289965cf181712c6c50
Source dataset
uspto-grants-2011_08
Patent number
US08003703B2

Reaction notes

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