Thionyl Chloride → 8-bromooctanoyl Chloride
Reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]([OH:11])=O.S(Cl)([Cl:14])=O>>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]([Cl:14])=[O:11]Participants
3
Procedure
8-Bromooctanoic acid (2.0 g, 8.97 mmol, commercially available e.g. from Aldrich) in thionyl chloride (2 ml) was stirred at room temperature for 1 hour and then at 100° C. for 2 hours. The thionyl chloride was removed by evaporation and the residue was co-evaporated with dichloromethane (2×30 ml) to give 8-bromooctanoyl chloride as a colourless mobile oil (2.05 g).
Workup
- customThe thionyl chloride was removed by evaporation
Sources & evidence
- ORD record
- ord-1ead752049a94bbdb14c97bf132d2cbe
- Source dataset
- uspto-grants-2011_08
- Patent number
- US08003663B2
Reaction notes
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