Thionyl Chloride → 8-bromooctanoyl Chloride

Participants

Reaction Steps

8-Bromooctanoic acid (2.0 g, 8.97 mmol, commercially available e.g. from Aldrich) in thionyl chloride (2 ml) was stirred at room temperature for 1 hour and then at 100° C. for 2 hours. The thionyl chloride was removed by evaporation and the residue was co-evaporated with dichloromethane (2×30 ml) to give 8-bromooctanoyl chloride as a colourless mobile oil (2.05 g).

Provenance & Evidence