HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 67348907, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-Amino-4-chlorophenol | HCID 5070078 | — |
| Reactant | 6-Bromo-4-chloroquinoline | HCID 5139537 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 67348907 | HCID 67348907 | 88% |
Reaction Steps
500 mg (2.06 mmol) of 6-bromo-4-chloroquinoline in 20 ml acetonitrile are mixed with 325 mg (2.27 mmol) of 3-amino-4-chlorophenol and 0.5 ml of 1 M HCl solution in dioxane and heated under reflux for 3 days. The crystals which have separated out are filtered off with suction and dried under high vacuum. 700 mg (70%) of the title compound are obtained as hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003787B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-cee273abeeb14740aec78b931e18b7a2 |
| Source note | uspto-grants-2011_08 |