Hydrochloric Acid → HCID 67348907, compound

HRID 1675719Notes

Reaction equation

HRID 1675719 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2[Cl:12].[NH2:13][C:14]1[CH:15]=[C:16]([OH:21])[CH:17]=[CH:18][C:19]=1[Cl:20].Cl>C(#N)C.O1CCOCC1>[ClH:12].[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2[NH:13][C:14]1[CH:15]=[C:16]([OH:21])[CH:17]=[CH:18][C:19]=1[Cl:20]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 50700783-Amino-4-chlorophenolHCID 51395376-Bromo-4-chloroquinoline

Product 1

HCID 67348907HCID 67348907, compoundYield 88%

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 312751,4-DioxaneSolvent

Procedure

500 mg (2.06 mmol) of 6-bromo-4-chloroquinoline in 20 ml acetonitrile are mixed with 325 mg (2.27 mmol) of 3-amino-4-chlorophenol and 0.5 ml of 1 M HCl solution in dioxane and heated under reflux for 3 days. The crystals which have separated out are filtered off with suction and dried under high vacuum. 700 mg (70%) of the title compound are obtained as hydrochloride.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 3 days
  3. customThe crystals which have separated out
  4. filtrationare filtered off with suction
  5. customdried under high vacuum

Sources & evidence

ORD record
ord-cee273abeeb14740aec78b931e18b7a2
Source dataset
uspto-grants-2011_08
Patent number
US08003787B2

Reaction notes

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