Tert-butyl (2-oxo-2,3-dihydrobenzimidazol-1-yl)acetate → (2-Oxo-3-pyrimidin-4-yl-2,3-dihydro-1H-benzimidazol-1-yl)acetic acid

HRID 1675752Notes

Reaction equation

HRID 1675752 reaction equation
O=C1N(CC(OC(C)(C)C)=O)C2C=CC=CC=2N1.[O:19]=[C:20]1[N:24]([CH2:25][C:26]([O:28]C(C)(C)C)=[O:27])[C:23]2[CH:33]=[CH:34][CH:35]=[CH:36][C:22]=2[N:21]1[C:37]1[CH:42]=[CH:41][N:40]=[CH:39][N:38]=1>>[O:19]=[C:20]1[N:24]([CH2:25][C:26]([OH:28])=[O:27])[C:23]2[CH:33]=[CH:34][CH:35]=[CH:36][C:22]=2[N:21]1[C:37]1[CH:42]=[CH:41][N:40]=[CH:39][N:38]=1

Participants

3

Reactant 2

HCID 20814117Tert-butyl (2-oxo-2,3-dihydrobenzimidazol-1-yl)acetateHCID 86607782tert-Butyl (2-oxo-3-pyrimidin-4-yl-2,3-dihydro-1H-benzimidazol-1-yl)acetate

Product 1

HCID 18449370(2-Oxo-3-pyrimidin-4-yl-2,3-dihydro-1H-benzimidazol-1-yl)acetic acid

Procedure

Essentially following the procedures described for Intermediate 7, but using tert-butyl (2-oxo-3-pyrimidin-4-yl-2,3-dihydro-1H-benzimidazol-1-yl)acetate from Step B in place of tert-butyl (2-oxo-3-pyridin-2-yl-2,3-dihydro-1H-benzimidazol-1-yl)acetate, the title compound was prepared. MS: m/z=271 (M+1).

Sources & evidence

ORD record
ord-a56650f3a2ab4698afb680506c12ff6b
Source dataset
uspto-grants-2011_08
Patent number
US08003792B2

Reaction notes

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