Trifluoroacetic acid → HCID 59279572, compound

HRID 1675781Notes

Reaction equation

HRID 1675781 reaction equation
C(C(O)=O)(F)(F)F.[O:8]=[C:9]1[N:13]([CH2:14][C:15]([O:17]C(C)(C)C)=[O:16])[C:12]2[CH:22]=[CH:23][CH:24]=[CH:25][C:11]=2[N:10]1[CH:26]1[CH2:31][CH2:30][S:29][CH2:28][CH2:27]1>C(Cl)Cl>[O:8]=[C:9]1[N:13]([CH2:14][C:15]([OH:17])=[O:16])[C:12]2[CH:22]=[CH:23][CH:24]=[CH:25][C:11]=2[N:10]1[CH:26]1[CH2:31][CH2:30][S:29][CH2:28][CH2:27]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86619736HCID 86619736, compound

Product 1

HCID 59279572HCID 59279572, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

CF3CO2H (1 mL) was added to a solution of tert-butyl (2-oxo-3-tetrahydro-2H-thiopyran-4-yl-2,3-dihydro-1H-benzimidazol-1-yl)acetate from Step C (169 mg, 0.485 mmol) in CH2Cl2 (3 mL). After 3 h, the mixture was concentrated in vacuo to give the title compound. MS: m/z=293 (M+1).

Workup

  1. concentrationthe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-00d1c81ca98140f9b06256f0561e18f3
Source dataset
uspto-grants-2011_08
Patent number
US08003792B2

Reaction notes

Loading…