Hydrochloric Acid → (2',4-Dioxospiro[cyclohexane-1,3'-indol]-1'(2'H)-yl)acetic acid

Participants

Reaction Steps

HCl (g) was bubbled into a solution of tert-butyl (2′,4-dioxospiro[cyclohexane-1,3′-indol]-1′(2′H)-yl)acetate from Step B (800 mg, 2.43 mmol) in EtOAc (10 mL) for 5 min. After 3 h, the reaction was concentrated in vacuo to give the desired product. MS: m/z=274 (M+1).

Provenance & Evidence