Hydrochloric Acid → HCID 59708346, compound

HRID 1675785Notes

Reaction equation

HRID 1675785 reaction equation
Cl.[O:2]=[C:3]1[C:11]2([CH2:16][CH2:15][C:14](=[O:17])[CH2:13][CH2:12]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]1[CH2:18][C:19]([O:21]C(C)(C)C)=[O:20]>CCOC(C)=O>[O:2]=[C:3]1[C:11]2([CH2:12][CH2:13][C:14](=[O:17])[CH2:15][CH2:16]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]1[CH2:18][C:19]([OH:21])=[O:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58026277HCID 58026277, compound

Product 1

HCID 59708346HCID 59708346, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

HCl (g) was bubbled into a solution of tert-butyl (2′,4-dioxospiro[cyclohexane-1,3′-indol]-1′(2′H)-yl)acetate from Step B (800 mg, 2.43 mmol) in EtOAc (10 mL) for 5 min. After 3 h, the reaction was concentrated in vacuo to give the desired product. MS: m/z=274 (M+1).

Workup

  1. concentrationthe reaction was concentrated in vacuo

Sources & evidence

ORD record
ord-b935d23c47eb4014b269820e11cb8162
Source dataset
uspto-grants-2011_08
Patent number
US08003792B2

Reaction notes

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