HCID 178470879, compound → HCID 178512522, compound

HRID 1676045Notes

Reaction equation

HRID 1676045 reaction equation
[NH2:1][C:2]([NH:4][C:5]1[CH:35]=[CH:34][C:8]([C:9]([NH:11][C:12]2[CH:33]=[CH:32][C:15]3[N:16]([CH:19]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[CH2:20][C:21]([O:23]CC)=[O:22])[CH:17]=[N:18][C:14]=3[CH:13]=2)=[O:10])=[CH:7][CH:6]=1)=[NH:3]>Cl>[NH2:3][C:2]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([C:9]([NH:11][C:12]2[CH:33]=[CH:32][C:15]3[N:16]([CH:19]([C:26]4[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=4)[CH2:20][C:21]([OH:23])=[O:22])[CH:17]=[N:18][C:14]=3[CH:13]=2)=[O:10])=[CH:34][CH:35]=1)=[NH:1]

Participants

3

Reactant 1

HCID 178470879HCID 178470879, compound

Product 1

HCID 178512522HCID 178512522, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of ethyl 3-{5-[(4-{[amino(imino)methyl]amino}benzoyl)amino]-1H-benzimidazol-1-yl}-3-phenylpropanoate (4.0 mg, 8.5 μmol) in hydrochloric acid (10 mL of a 5N solution) was stirred at room temperature for 72 hours. The solution was then evaporated in vacuo to afford the title compound, [LCMS (Method A, Mobile Phase II) RT=2.95 min, MH+ 443].

Workup

  1. customThe solution was then evaporated in vacuo

Sources & evidence

ORD record
ord-93040b37fb814e67aa69ef5939abec09
Source dataset
uspto-grants-2011_08
Patent number
US08003806B2

Reaction notes

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