HCID 178470876, compound → HCID 178512494, compound

HRID 1676066Notes

Reaction equation

HRID 1676066 reaction equation
[NH2:1][C:2]([NH:4][C:5]1[CH:6]=[C:7]([CH:33]=[CH:34][CH:35]=1)[C:8]([NH:10][C:11]1[CH:12]=[CH:13][C:14]2[N:18]=[CH:17][N:16]([CH:19]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH2:20][C:21]([O:23]CC)=[O:22])[C:15]=2[CH:32]=1)=[O:9])=[NH:3]>Cl>[NH2:3][C:2]([NH:4][C:5]1[CH:6]=[C:7]([CH:33]=[CH:34][CH:35]=1)[C:8]([NH:10][C:11]1[CH:12]=[CH:13][C:14]2[N:18]=[CH:17][N:16]([CH:19]([C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=3)[CH2:20][C:21]([OH:23])=[O:22])[C:15]=2[CH:32]=1)=[O:9])=[NH:1]

Participants

3

Reactant 1

HCID 178470876HCID 178470876, compound

Product 1

HCID 178512494HCID 178512494, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of ethyl 3-{6-[(3-{[amino(imino)methyl]amino}benzoyl)amino]-1H-benzimidazol-1-yl}-3-phenylpropanoate (24 mg, 51 μmol) in hydrochloric acid (20 mL of a 5N solution) was stirred at room temperature for 72 hours. The solution was evaporated in vacuo, and the residue was purified by RP-HPLC to afford the title compound, [LCMS (Method A, Mobile Phase II) RT=2.96 min, MH+ 443].

Workup

  1. customThe solution was evaporated in vacuo
  2. customthe residue was purified by RP-HPLC

Sources & evidence

ORD record
ord-9cfad0a738974b24b01f83001ed497c8
Source dataset
uspto-grants-2011_08
Patent number
US08003806B2

Reaction notes

Loading…