HCID 58653692, compound → HCID 58653707, compound

HRID 1676086Notes

Reaction equation

HRID 1676086 reaction equation
[C:1]1([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:6]=[CH:5][C:4]([CH:7]([N:13]2[C:17]3[CH:18]=[CH:19][C:20]([N+:22]([O-:24])=[O:23])=[CH:21][C:16]=3[N:15]=[CH:14]2)[CH2:8][C:9]([O:11]C)=[O:10])=[CH:3][CH:2]=1>Cl>[C:1]1([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:2]=[CH:3][C:4]([CH:7]([N:13]2[C:17]3[CH:18]=[CH:19][C:20]([N+:22]([O-:24])=[O:23])=[CH:21][C:16]=3[N:15]=[CH:14]2)[CH2:8][C:9]([OH:11])=[O:10])=[CH:5][CH:6]=1

Participants

3

Reactant 1

HCID 58653692HCID 58653692, compound

Product 1

HCID 58653707HCID 58653707, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of methyl 3-(1,1′-biphenyl)-4-yl-3-(5-nitro-1H-benzimidazol-1-yl)propanoate (21 mg, 52 μmol) in hydrochloric acid (10 mL of a 5N solution) was stirred at room temperature for 48 hours. The solution was evaporated in vacuo to afford the title compound, [LCMS (Method A, Mobile Phase I) RT=5.63 min, MH+ 388].

Workup

  1. customThe solution was evaporated in vacuo

Sources & evidence

ORD record
ord-780a6f3ccbd7465aa51cbc860a24c558
Source dataset
uspto-grants-2011_08
Patent number
US08003806B2

Reaction notes

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