反应详情

To a solution of methyl 3-(1,1′-biphenyl)-4-yl-3-(5-nitro-1H-benzimidazol-1-yl)propanoate (47 mg, 117 μmol) in ethanol (2 mL) was added palladium on carbon (9.0 mg, 10% active Pd), ammonium formate (37 mg, 587 μmol) and water (0.5 mL). The solution was heated at reflux for 4 hours, the cooled to room temperature, and filtered through Celite®. The filtrate was evaporated in vacuo, and the residue was purified by flash column chromatography on silica gel, eluting with a mixture of dichloromethane and methanol (97:3) to afford the title compound, [LCMS (Method B, Mobile Phase I) RT=2.26 min, MH+ 372].

1. temperatureThe solution was heated
2. temperatureat reflux for 4 hours
3. filtrationfiltered through Celite®
4. customThe filtrate was evaporated in vacuo
5. customthe residue was purified by flash column chromatography on silica gel
6. washeluting with a mixture of dichloromethane and methanol (97:3)