HCID 58653660, compound → HCID 58653651, compound

HRID 1676090Notes

Reaction equation

HRID 1676090 reaction equation
[C:1]1([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:6]=[CH:5][C:4]([CH:7]([N:13]2[C:17]3[CH:18]=[CH:19][C:20]([NH:22][S:23]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)(=[O:25])=[O:24])=[CH:21][C:16]=3[N:15]=[CH:14]2)[CH2:8][C:9]([O:11]C)=[O:10])=[CH:3][CH:2]=1>Cl>[C:1]1([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:2]=[CH:3][C:4]([CH:7]([N:13]2[C:17]3[CH:18]=[CH:19][C:20]([NH:22][S:23]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)(=[O:25])=[O:24])=[CH:21][C:16]=3[N:15]=[CH:14]2)[CH2:8][C:9]([OH:11])=[O:10])=[CH:5][CH:6]=1

Participants

3

Reactant 1

HCID 58653660HCID 58653660, compound

Product 1

HCID 58653651HCID 58653651, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of methyl 3-(1,1′-biphenyl)-4-yl-3-{5-[(phenylsulfonyl)amino]-1H-benzimidazol-1-yl}propanoate (12 mg, 23 μmol) in hydrochloric acid (10 mL of a 5N solution) was stirred at room temperature for 120 hours. The solution was evaporated in vacuo to afford the title compound, [LCMS (Method A, Mobile Phase I) RT=5.04 min, MH+ 498].

Workup

  1. customThe solution was evaporated in vacuo

Sources & evidence

ORD record
ord-503b3f5dac8f4d969e5e2e4f13b0c050
Source dataset
uspto-grants-2011_08
Patent number
US08003806B2

Reaction notes

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