Acetonitrile → HCID 11682467, compound

HRID 1676093Notes

Reaction equation

HRID 1676093 reaction equation
[NH:1]([C:8]([C:10]1[CH:31]=[CH:30][C:13]2[N:14]([CH:17]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:18][C:19]([O:21]CC)=[O:20])[CH:15]=[N:16][C:12]=2[CH:11]=1)=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(#N)C>Cl>[NH:1]([C:8]([C:10]1[CH:31]=[CH:30][C:13]2[N:14]([CH:17]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[CH2:18][C:19]([OH:21])=[O:20])[CH:15]=[N:16][C:12]=2[CH:11]=1)=[O:9])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6342AcetonitrileHCID 58653679HCID 58653679, compound

Product 1

HCID 11682467HCID 11682467, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of ethyl 3-[5-(anilinocarbonyl)-1H-benzimidazol-1-yl]-3-phenylpropanoate (27 mg, 65 μmol) in a mixture of hydrochloric acid (20 mL of a 5N solution) and acetonitrile (15 mL) was stirred at room temperature for 96 hours. The resulting suspension was then concentrated and filtered, and the resulting solid dried in vacuo over P2O5 to afford the title compound, [LCMS (Method A, Mobile Phase I) RT=4.54 min, MH+ 386].

Workup

  1. concentrationThe resulting suspension was then concentrated
  2. filtrationfiltered
  3. dry with materialthe resulting solid dried in vacuo over P2O5

Sources & evidence

ORD record
ord-f9b0c7b06eb24f1eb2fd79362adec46b
Source dataset
uspto-grants-2011_08
Patent number
US08003806B2

Reaction notes

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