Acetonitrile → 4-Isobutyl-3,5-dimethylthiophene-2-carboxylic acid

HRID 1676114Notes

Reaction equation

HRID 1676114 reaction equation
[CH2:1]([C:5]1[CH:6]=[C:7]([C:11]([OH:13])=[O:12])[S:8][C:9]=1[CH3:10])[CH:2]([CH3:4])[CH3:3].[CH3:14]C#N>>[CH2:1]([C:5]1[C:6]([CH3:14])=[C:7]([C:11]([OH:13])=[O:12])[S:8][C:9]=1[CH3:10])[CH:2]([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 6342AcetonitrileHCID 594978744-Isobutyl-5-methylthiophene-2-carboxylic acid

Product 1

HCID 594978664-Isobutyl-3,5-dimethylthiophene-2-carboxylic acid

Procedure

4-Isobutyl-3,5-dimethyl-thiophene-2-carboxylic acid is prepared from 4-isobutyl-5-methyl-thiophene-2-carboxylic acid in analogy to Intermediate A2; LC-MS: tR=0.97 min, [M+1+CH3CN]=254.26; 1H NMR (CDCl3): δ 2.46 (s, 3H), 2.39 (s, 3H), 2.36 (d, J=7.0 Hz, 2H), 1.78 (hept, J=7.0 Hz, 1H), 0.91 (d, J=7.0 Hz, 6H).

Sources & evidence

ORD record
ord-6437473ab1704749b9e96aa955cdd9b7
Source dataset
uspto-grants-2011_08
Patent number
US08003800B2

Reaction notes

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