反应详情

A 100 ml-four-necked flask equipped with a thermometer, a reflux condenser, and a stirrer was charged with 8.61 g (102) mmol 2-methyl-3-butin-2-ol (MBI) and 30.14 g (102 mmol) 3,7,11,15-tetramethyl-1-hexadecin-3-ol (DIP) stirred with 750 rpm and heated up to reflux temperature. After 5 min an internal temperature of 95° C. was reached, and 2 ml KOH (41.42% in H2O, 20.53 mmol) were added. The reaction was controlled by GC (samples were taken after 60 min, 155 min and 385 min). The ketones were separated by distillation. Yield acetone 5.8 g, (97.5%), yield 6,10,14-trimethyl-2-pentadecanon (C18—K) 26.1 g, (96.1%), not optimized.

1. customA 100 ml-four-necked flask equipped with a thermometer, a reflux condenser, and a stirrer
2. temperatureheated up
3. temperatureto reflux temperature
4. customwas controlled by GC (samples were taken after 60 min, 155 min and 385 min)
5. customThe ketones were separated by distillation