2-Methyl-3-butyn-2-ol → 2-pentadecanone, 6,10,14-trimethyl-

Participants

Reaction Steps

A 100 ml-four-necked flask equipped with a thermometer, a reflux condenser, and a stirrer was charged with 8.61 g (102) mmol 2-methyl-3-butin-2-ol (MBI) and 30.14 g (102 mmol) 3,7,11,15-tetramethyl-1-hexadecin-3-ol (DIP) stirred with 750 rpm and heated up to reflux temperature. After 5 min an internal temperature of 95° C. was reached, and 2 ml KOH (41.42% in H2O, 20.53 mmol) were added. The reaction was controlled by GC (samples were taken after 60 min, 155 min and 385 min). The ketones were separated by distillation. Yield acetone 5.8 g, (97.5%), yield 6,10,14-trimethyl-2-pentadecanon (C18—K) 26.1 g, (96.1%), not optimized.

Provenance & Evidence