(Trifluoromethyl)trimethylsilane → HCID 57516616, compound

To a stirred solution of benzyl 4-oxopiperidine-1-carboxylate (308 g, 1.32 mol) in THF (1 L) cooled in an ice bath was added trimethyl(trifluoromethyl)silane (229 g, 1.61 mol) via an addition funnel over a period of 15 minutes. A 1.0 M solution of TBAF in THF (13.2 mL, 13.2 mmol) was slowly added dropwise to the mixture. After being stirred for 16 hours at ambient temperature, the mixture was charged with additional trimethyl(trifluoromethyl)silane (25.0 g, 176 mmol) and stirred for 2 hours. The mixture was concentrated to a volume of 500 mL, diluted with MeOH (3 L), cooled in an ice bath, and carefully quenched with concentrated aqueous HCl (250 mL). The mixture was removed from the ice bath, stirred for 1 hour, and concentrated in vacuo. The resulting aqueous suspension was extracted with CH2Cl2 (1 L, then 2×500 mL). The combined CH2Cl2 extracts were dried (MgSO4), filtered, and concentrated. The crude material was crystallized from toluene to give 357 g (89%) of product as a white solid.

1. stirringstirred for 2 hours
2. concentrationThe mixture was concentrated to a volume of 500 mL
3. additiondiluted with MeOH (3 L)
4. temperaturecooled in an ice bath
5. customcarefully quenched with concentrated aqueous HCl (250 mL)
6. customThe mixture was removed from the ice bath
7. stirringstirred for 1 hour
8. concentrationconcentrated in vacuo
9. extractionThe resulting aqueous suspension was extracted with CH2Cl2 (1 L
10. dry with materialThe combined CH2Cl2 extracts were dried (MgSO4)
11. filtrationfiltered
12. concentrationconcentrated
13. customThe crude material was crystallized from toluene

ORD record

ord-05790c400d834f578d3a83b204442fe0

Source dataset

uspto-grants-2011_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08003662B2