Dietylaminopropin → HCID 67347436, compound

HRID 1676271Notes

Reaction equation

I[C:2]1[S:10][C:9]2[C:4](=[N:5][CH:6]=[CH:7][C:8]=2[O:11][C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[C:14]([CH3:19])[CH:13]=2)[CH:3]=1.[CH2:20]([N:22]([CH2:26][CH3:27])[CH2:23][C:24]#[CH:25])[CH3:21]>>[CH2:20]([N:22]([CH2:26][CH3:27])[CH2:23][C:24]#[C:25][C:2]1[S:10][C:9]2[C:4](=[N:5][CH:6]=[CH:7][C:8]=2[O:11][C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[C:14]([CH3:19])[CH:13]=2)[CH:3]=1)[CH3:21]

Participants

Reactant 2

HCID 20010Dietylaminopropin

HCID 67348108HCID 67348108, compound

Product 1

HCID 67347436HCID 67347436, compound

Procedure

Prepared from 4-(2-iodothieno[3,2-b]pyridin-7-yloxy)-2-methylbenzenamine (0.250 g, 0.556 mmol), and N,N-diethylprop-2-yn-1-amine (0.0680 g, 0.612 mmol), according to the procedure for Example 6, Step B. The crude was purified by Biotage 40S (EtOAc). The product was an orange oil (116 mg, 39%). LRMS (ESI pos) m/e 366 (M+1).

Workup

customThe crude was purified by Biotage 40S (EtOAc)

Sources & evidence

ORD record: ord-b3c0fb8ff8744f3397223cf01e4b0885
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08003662B2

Reaction notes

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