HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Methylcarbamoyl)benzeneboronic acid → 4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)-N-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Methylcarbamoyl)benzeneboronic acid | HCID 2773526 | — |
| Reactant | 3-Fluoro-4-((2-iodothieno[3,2-b]pyridin-7-yl)oxy)aniline | HCID 58474950 | — |
| Product | 4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)-N-methylbenzamide | HCID 67348698 | 96% |
Reaction Steps
Prepared from 3-fluoro-4-(2-iodothieno[3,2-b]pyridin-7-yloxy)benzenamine (Example 6, Step A; 0.300 g, 0.777 mmol) and 4-(methylcarbamoyl)phenylboronic acid (0.174 g, 0.971 mmol) according to the procedure described for Example 94, Step A. Purified by trituration from hot MeOH to obtain the product (210 mg, 96%) as a brown solid. LRMS (APCI pos) m/e 394 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003662B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-cc6500c8e9f3449fac96d5333fb78dc6 |
| Source note | uspto-grants-2011_08 |