反应详情

A flask was charged with methyl 2-oxopyrrolidine-3-carboxylate (500 mg, 3.49 mmol), potassium trimethylsilanolate (1344 mg, 10.48 mmol) and THF (10 mL). The reaction mixture was stirred at room temperature until the starting material had been consumed (overnight). Then HCl (20 mL, 2.0M in Et2O) was added and the mixture was stirred for 30 minutes. Then the mixture was filtered to remove the solid and the solvent was removed under reduced pressure to give the crude product (188.7 mg, 41.84%), which was used for next step without further purification.

1. customhad been consumed (overnight)
2. additionThen HCl (20 mL, 2.0M in Et2O) was added
3. stirringthe mixture was stirred for 30 minutes
4. filtrationThen the mixture was filtered
5. customto remove the solid
6. customthe solvent was removed under reduced pressure