反应详情

温度

110 °C

A microwave vial was charged with ethyl 2-chloronicotinate (0.209 g, 1.13 mmol), Cs2CO3 (0.331 g, 1.01 mmol), tert-butyl 4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)piperidine-1-carboxylate (Example 154, Step A, 0.200 g, 0.451 mmol), Palladium acetate (0.0101 g, 0.0451 mmol), PdCl2(dppf)-dcm (0.0185 g, 0.0225 mmol), toluene (2 mL) and EtOH (1 mL). The mixture was heated to 110° C. for 3 hours. After cooling to room temperature, the mixture was diluted with water and extracted with EtOAc. The organics were isolated and dried (MgSO4). After filtration and concentration, the crude product was purified by preparative TLC (2.0 mm thickness, eluting with EtOAc. The product (175 mg, 59%) was isolated as a yellow solid. LRMS (esi+)593 m/z (M+1) detected.

1. temperatureAfter cooling to room temperature
2. extractionextracted with EtOAc
3. customThe organics were isolated
4. dry with materialdried (MgSO4)
5. filtrationAfter filtration and concentration
6. customthe crude product was purified by preparative TLC (2.0 mm thickness
7. washeluting with EtOAc