Hydrochloric Acid → 1201694-08-7

HRID 1676521Notes

Reaction equation

HRID 1676521 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH:15]([F:17])[F:16])[CH2:10][CH2:9]1)(C)(C)C.[ClH:19]>O1CCOCC1>[ClH:19].[ClH:19].[F:17][CH:15]([F:16])[CH2:14][N:11]1[CH2:10][CH2:9][CH:8]([NH2:7])[CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86637500[1-(2,2-Difluoro-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

Product 1

HCID 754807781201694-08-7

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a cooled (0 degrees) mixture of 1.21 g (4.58 mmole) of [1-(2,2-difluoro-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester and 20 mL of dioxane, was added 5.7 mL of 4M HCl in dioxane. The mixture was stirred at room temperature overnight, and the solid collected by filtration to give 0.90 g of 1-(2,2-difluoro-ethyl)-piperidin-4-ylamine dihydrochloride.

Workup

  1. temperatureTo a cooled
  2. filtrationthe solid collected by filtration

Sources & evidence

ORD record
ord-e09a25ffa64343cc9ed69e9edec03e59
Source dataset
uspto-grants-2011_08
Patent number
US08003785B2

Reaction notes

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