Hydrochloric Acid → 1-(3-Methanesulfonyl-propyl)-piperidin-4-ylamine dihydrochloride

HRID 1676526Notes

Reaction equation

HRID 1676526 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][S:17]([CH3:20])(=[O:19])=[O:18])[CH2:10][CH2:9]1)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[ClH:22].[CH3:20][S:17]([CH2:16][CH2:15][CH2:14][N:11]1[CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9][CH2:10]1)(=[O:19])=[O:18]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67355480[1-(3-Methanesulfonyl-propyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

Product 1

HCID 673553041-(3-Methanesulfonyl-propyl)-piperidin-4-ylamine dihydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a cooled (0 degrees) mixture of 3.6 g (0.0113 mole) of [1-(3-methanesulfonyl-propyl)-piperidin-4-yl]-carbamic acid tert-butyl ester and 30 mL of dioxane, was added 14.1 mL of 4M HCl in dioxane. The mixture was stirred 18 hours at room temperature, and the solid collected by filtration to give 2.3 g of 1-(3-methanesulfonyl-propyl)-piperidin-4-ylamine dihydrochloride.

Workup

  1. temperatureTo a cooled
  2. filtrationthe solid collected by filtration

Sources & evidence

ORD record
ord-7c4232b425dd4a1f8999d9e3ac9d02d4
Source dataset
uspto-grants-2011_08
Patent number
US08003785B2

Reaction notes

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