反应详情

To a cooled (0 degrees) mixture of 3.6 g (0.0113 mole) of [1-(3-methanesulfonyl-propyl)-piperidin-4-yl]-carbamic acid tert-butyl ester and 30 mL of dioxane, was added 14.1 mL of 4M HCl in dioxane. The mixture was stirred 18 hours at room temperature, and the solid collected by filtration to give 2.3 g of 1-(3-methanesulfonyl-propyl)-piperidin-4-ylamine dihydrochloride.

1. temperatureTo a cooled
2. filtrationthe solid collected by filtration