反应详情

To a solution of 1.0 g (4.2 mole) of 3-isopropoxy-4-nitro-benzoic acid methyl ester in 20 mL of methanol was added 8.4 mL (8.4 mole) of 1M lithium hydroxide. The mixture was stirred at room temperature for 2 hours. The mixture was partially concentrated under reduced pressure and then acidified to by addition of 1 M of hydrochloric acid. The solid, which formed, was collected by filtration, washed with water and dried under vacuum to give 0.93 g of 3-isopropoxy-4-nitro-benzoic acid as a white solid.

1. concentrationThe mixture was partially concentrated under reduced pressure
2. additionacidified to by addition of 1 M of hydrochloric acid
3. customThe solid, which formed
4. filtrationwas collected by filtration
5. washwashed with water
6. customdried under vacuum