Methanol → Trifluoroacetic acid

HRID 167656Notes

Reaction equation

HRID 167656 reaction equation
[CH3:26][OH:27].[CH:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[N:14]1[CH2:15][CH:16]([OH:18])[CH2:17]1.[F:19][C:20]([C:21](=[O:22])[OH:23])([F:24])[F:25].[OH-:28].[OH-:30].[Pd+2:29]>>[F:19][C:20]([C:21](=[O:22])[OH:23])([F:24])[F:25].[NH:14]1[CH2:15][CH:16]([OH:18])[CH2:17]1

Participants

7

Reactant 5

HCID 887MethanolHCID 961Hydroxide2×HCID 6422Trifluoroacetic acidHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 3304481-(Diphenylmethyl)azetidin-3-ol

Product 2

HCID 6422Trifluoroacetic acidHCID 15142903-Hydroxyazetidine

Sources & evidence

ORD record
ord-7ca69cb6e6d6400ab28eb38a5cf8a13b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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