反应详情

温度

150 °C

1,2-Dimethyl-piperazine (0.914 g, 8.00 mmol) and ethyl 4-fluorobenzoate (0.587 mL, 4 mmol) were dissolved in DMA (6 mL) and sealed into a microwave tube. The reaction was heated to 150° C. for 90 mins in the microwave reactor and cooled to room temperature. The reaction mixture was evaporated and the crude product was purified by silica column chromatography, eluting with 5% MeOH in DCM (containing 0.1% 0.880 ammonia). Pure fractions were evaporated to dryness to afford ethyl 4-(3,4-dimethylpiperazin-1-yl)benzoate (0.380 g, 36.2%) as a colourless waxy solid.

1. customsealed into a microwave tube
2. temperaturecooled to room temperature
3. customThe reaction mixture was evaporated
4. customthe crude product was purified by silica column chromatography
5. washeluting with 5% MeOH in DCM (containing 0.1% 0.880 ammonia)
6. customPure fractions were evaporated to dryness