tert-Butyl 1-(2,2,2-trifluoroethyl)piperidin-4-ylcarbamate → 1-(2,2,2-Trifluoroethyl)piperidin-4-amine

HRID 1676621노트

반응식

HRID 1676621 반응식
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]([F:18])([F:17])[F:16])[CH2:10][CH2:9]1)(C)(C)C>Cl.O1CCOCC1>[F:18][C:15]([F:16])([F:17])[CH2:14][N:11]1[CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9][CH2:10]1

참가 물질

4

반응물 1

HCID 22562166tert-Butyl 1-(2,2,2-trifluoroethyl)piperidin-4-ylcarbamate

생성물 1

HCID 162287221-(2,2,2-Trifluoroethyl)piperidin-4-amine수율 112.2%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 312751,4-Dioxane용매

실험 절차

A suspension of 1.26 g (0.0045 mole) of [1-(2,2,2-trifluoro-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester in 10 mL of 4 M HCl in dioxane solution was stirred at room temperature for 24 hours. Volatiles were removed under reduced pressure, methanol was added to the residue followed by ether. The resulting solid was collected by filtration, washing with ether to give 0.92 g of 1-(2,2,2-trifluoro-ethyl)-piperidin-4-ylamine; hydrochloride as a white solid.

후처리

  1. customVolatiles were removed under reduced pressure, methanol
  2. additionwas added to the residue
  3. filtrationThe resulting solid was collected by filtration
  4. washwashing with ether

출처 및 근거

ORD 기록
ord-a86379d78f344b33b35efea072d58eaa
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08003785B2

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