反应详情

A suspension of 1.26 g (0.0045 mole) of [1-(2,2,2-trifluoro-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester in 10 mL of 4 M HCl in dioxane solution was stirred at room temperature for 24 hours. Volatiles were removed under reduced pressure, methanol was added to the residue followed by ether. The resulting solid was collected by filtration, washing with ether to give 0.92 g of 1-(2,2,2-trifluoro-ethyl)-piperidin-4-ylamine; hydrochloride as a white solid.

1. customVolatiles were removed under reduced pressure, methanol
2. additionwas added to the residue
3. filtrationThe resulting solid was collected by filtration
4. washwashing with ether