HCID 24772584, compound → HCID 24772585, compound

HRID 1676846Notes

Reaction equation

HRID 1676846 reaction equation
C([O:8][CH2:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19][C:20](=[O:30])[CH2:21][O:22]CC2C=CC=CC=2)=[CH:15][CH:14]=1)=[O:11])C1C=CC=CC=1>CO.[Pd]>[OH:8][CH2:9][C:10]([NH:12][C:13]1[CH:14]=[CH:15][C:16]([NH:19][C:20](=[O:30])[CH2:21][OH:22])=[CH:17][CH:18]=1)=[O:11]

Participants

4

Reactant 1

HCID 24772584HCID 24772584, compound

Product 1

HCID 24772585HCID 24772585, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2-Benzyloxy-N-[4-(2-benzyloxy-acetylamino)-phenyl]-acetamide 3 (10 grams, 24.75 mmol) is dissolved in methanol (100 mL) in a pressure vessel. Pd/C (10%, 3 grams) is added, and the mixture is stirred under an atmosphere of hydrogen (4 Kg) for 5 hours. The catalyst is removed by filtration, and the methanol is distilled off. The crude 4 can be purified in a suitable solvent.

Workup

  1. customThe catalyst is removed by filtration
  2. distillationthe methanol is distilled off
  3. customThe crude 4 can be purified in a suitable solvent

Sources & evidence

ORD record
ord-a8c58661f67a466fb8fefed2a024cbf2
Source dataset
uspto-grants-2011_08
Patent number
US08007526B2

Reaction notes

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