HCID 24772586, compound → HCID 24772587, compound

HRID 1676848Notes

Reaction equation

HRID 1676848 reaction equation
[CH3:1][O:2][C:3]([CH2:5][O:6][C:7](=[O:26])[C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:25])[CH2:16][O:17]CC2C=CC=CC=2)=[CH:10][CH:9]=1)=[O:4]>CO.[Pd]>[CH3:1][O:2][C:3]([CH2:5][O:6][C:7](=[O:26])[C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:25])[CH2:16][OH:17])=[CH:10][CH:9]=1)=[O:4]

Participants

4

Reactant 1

HCID 24772586HCID 24772586, compound

Product 1

HCID 24772587HCID 24772587, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

4-(2-Benzyloxy-acetylamino)-benzoic acid methoxycarbonylmethyl ester 7 (10 grams, 28.98 mmol) is dissolved in methanol (100 mL) in a pressure vessel. Pd/C (10%, 3 grams) is added, and the mixture is stirred under an atmosphere of hydrogen (4 Kg) for 5 hours. The catalyst is removed by filtration, and the methanol is distilled off. The crude 8 can be purified in a suitable solvent.

Workup

  1. customThe catalyst is removed by filtration
  2. distillationthe methanol is distilled off
  3. customThe crude 8 can be purified in a suitable solvent

Sources & evidence

ORD record
ord-55e5e1976c354bcd82b5d8f5250a6a73
Source dataset
uspto-grants-2011_08
Patent number
US08007526B2

Reaction notes

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