HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → N,N-dibenzyl 5-aminosulfonyl-4-chloro-2-[(2-furanylmethyl)amino]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Furosemide | HCID 3440 | — |
| Reactant | Dibenzylamine | HCID 7656 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N,N-dibenzyl 5-aminosulfonyl-4-chloro-2-[(2-furanylmethyl)amino]benzamide | HCID 11699128 | — |
Reaction Steps
In similar manner to Example 8, furosemide can be reacted with EDC, HOBt and dibenzylamine in DMF to yield N,N-dibenzyl 5-aminosulfonyl-4-chloro-2-[(2-furanylmethyl)amino]benzamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008283B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-f361f889f77c4f04927c91aee81b1e5e |
| Source note | uspto-grants-2011_08 |