HRID1676932

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11

1,2-Dichloroethane

C2H4Cl2

结构：NS(=O)(=O)c1cc(C(=O)O)c(NCc2ccco2)cc1Cl

HCID3440

Furosemide

C12H11ClN2O5S

HCID7656

Dibenzylamine

C14H15N

HCID75771

1-Hydroxybenzotriazole

C6H5N3O

PRODUCTS

生成物

结构：NS(=O)(=O)c1cc(C(=O)N(Cc2ccccc2)Cc2ccccc2)c(NCc2ccco2)cc1Cl

HCID11699128

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

In similar manner to Example 8, furosemide can be reacted with EDC, HOBt and dibenzylamine in DMF to yield N,N-dibenzyl 5-aminosulfonyl-4-chloro-2-[(2-furanylmethyl)amino]benzamide.