HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azosemide → 5-[1-(t-Butylcarbonyloxymethyl)-1H-tetrazol-5-yl]-2-chloro-4-[(2-thienylmethyl)amino]benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azosemide | HCID 2273 | — |
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Chloromethyl pivalate | HCID 87885 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-[1-(t-Butylcarbonyloxymethyl)-1H-tetrazol-5-yl]-2-chloro-4-[(2-thienylmethyl)amino]benzenesulfonamide | HCID 60208421 | — |
Reaction Steps
In a similar manner to Example 12, azosemide can be reacted with chloromethyl pivalate, triethylamine and sodium iodide in DMF to yield 5-[1-(t-Butylcarbonyloxymethyl)-1H-tetrazol-5-yl]-2-chloro-4-[(2-thienylmethyl)amino]benzenesulfonamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008283B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-0c1dfbcca0684062a244ca47d8938754 |
| Source note | uspto-grants-2011_08 |