HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azosemide → 2-chloro-5-[1-(ethylcarbonyloxymethyl)-1H-tetrazol-5-yl]-4-[(2-thienylmethyl)amino]benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azosemide | HCID 2273 | — |
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Chloromethyl propionate | HCID 221144 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-chloro-5-[1-(ethylcarbonyloxymethyl)-1H-tetrazol-5-yl]-4-[(2-thienylmethyl)amino]benzenesulfonamide | HCID 60208422 | — |
Reaction Steps
In similar manner to Example 12, azosemide can be reacted with chloromethyl propionate, triethylamine and sodium iodide in DMF to yield 2-chloro-5-[1-(ethylcarbonyloxymethyl)-1H-tetrazol-5-yl]-4-[(2-thienylmethyl)amino]benzenesulfonamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008283B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-df422ec5a938464195bf4e267dcdbce1 |
| Source note | uspto-grants-2011_08 |