HRID1676936

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：NS(=O)(=O)c1cc(-c2nn[nH]n2)c(NCc2cccs2)cc1Cl

HCID2273

Azosemide

C12H11ClN6O2S2

HCID5238

Sodium Iodide

INa

HCID8471

Triethylamine

C6H15N

HCID221144

Chloromethyl propanoate

C4H7ClO2

PRODUCTS

生成物

结构：CCC(=O)OCn1nnnc1-c1cc(S(N)(=O)=O)c(Cl)cc1NCc1cccs1

HCID60208422

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

In similar manner to Example 12, azosemide can be reacted with chloromethyl propionate, triethylamine and sodium iodide in DMF to yield 2-chloro-5-[1-(ethylcarbonyloxymethyl)-1H-tetrazol-5-yl]-4-[(2-thienylmethyl)amino]benzenesulfonamide.