4-(Morpholine-4-sulfonyl)benzoic acid → HCID 15951135, compound

HRID 1676952Notes

Reaction equation

HRID 1676952 reaction equation
[N:1]1([S:7]([C:10]2[CH:18]=[CH:17][C:13]([C:14]([OH:16])=O)=[CH:12][CH:11]=2)(=[O:9])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[NH:19]1[CH2:23][CH2:22][CH2:21][C@H:20]1[CH2:24][N:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1>>[N:1]1([S:7]([C:10]2[CH:11]=[CH:12][C:13]([C:14]([N:19]3[CH2:23][CH2:22][CH2:21][C@H:20]3[CH2:24][N:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)=[O:16])=[CH:17][CH:18]=2)(=[O:8])=[O:9])[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 5594164-(Morpholine-4-sulfonyl)benzoic acidHCID 853152(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine

Product 1

HCID 15951135HCID 15951135, compoundYield 35.8%

Procedure

The title compound is prepared from 4-(morpholine-4-sulfonyl)-benzoic acid (407 mg, 1.5 mmol) and (S)(+)-1-(2-pyrrolidinylmethyl)pyrrolidine (CAS 51207-66-0)(193 mg, 1.2 mmol) in a manner substantially similar to Procedure G to provide 175 mg (34%) of the title compound. MS (ES+) 408.3 (M+H)+.

Sources & evidence

ORD record
ord-fdb941e327e94692910d1ad26f3b0380
Source dataset
uspto-grants-2011_08
Patent number
US08008296B2

Reaction notes

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