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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1676953Generated: October 30, 2026

4-(Chlorosulfonyl)benzoic acid → 4-[3-(Methanesulfonyl)pyrrolidine-1-sulfonyl]benzoic acid

https://huagongshe.com/reaction/1676953

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Chlorosulfonyl)benzoic acidHCID 82385—
Reactant3-(methylsulfonyl)pyrrolidineHCID 3419356—
Product4-[3-(Methanesulfonyl)pyrrolidine-1-sulfonyl]benzoic acidHCID 6717644644.1%

Reaction Steps

The title intermediate is prepared from 4-(chlorosulfonyl)benzoic acid (CAS 10130-89-9) (375 mg, 1.7 mmol) and 3-(methylsulfonyl)pyrrolidine (CAS 433980-62-2) (343 mg, 2.3 mmol) in a manner substantially similar to Procedure F to provide 250 mg (44%) of the title compound. MS (ES−) 332.0 (M−H)−.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08008296B2
Source datasetuspto-grants-2011_08
ORD IDord-81b09e6f99174fd0a0c61c2c1e70c410
Source noteuspto-grants-2011_08