HuagongsheHuagongshe Chemistry Print Report · For research reference only
((1,4-Dioxan-2-yl)methyl)(methyl)amine → (+/-)-5-Bromo-3-{[(1,4-dioxan-2-ylmethyl)(methyl)amino]sulfonyl}-1H-indole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | ((1,4-Dioxan-2-yl)methyl)(methyl)amine | HCID 3614772 | — |
| Reactant | Methylamine hydrochloride | HCID 6364545 | — |
| Reactant | ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate | HCID 22401482 | — |
| Reactant | ethyl 3-(chlorosulfonyl)-5-bromo-1-(phenylsulfonyl)-1H-indole-2-carboxylate | HCID 86592455 | — |
| Product | (+/-)-5-Bromo-3-{[(1,4-dioxan-2-ylmethyl)(methyl)amino]sulfonyl}-1H-indole-2-carboxamide | HCID 58659663 | — |
Reaction Steps
Following the procedures described in Steps D and E of Example 1, replacing in Step D ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate with ethyl 5-bromo-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate, and methylamine hydrochloride with (±)-N-methyl-N-(1,4-dioxan-2-ylmethyl)amine, the title compound was obtained. Proton NMR for the product was consistent with the titled compound. ESI+ MS: 432.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008295B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-d7dadee4f240427f95272079259f46f6 |
| Source note | uspto-grants-2011_08 |