4-Methylsulfonylbenzylamine hydrochloride → HCID 10074131, compound

HRID 1676991Notes

Reaction equation

HRID 1676991 reaction equation
ClC1C=C2C(=CC=1)[N:7](S(C1C=CC=CC=1)(=O)=O)C(C(OCC)=O)=C2S(Cl)(=O)=O.[Br:29][C:30]1[CH:31]=[C:32]2[C:36](=[CH:37][CH:38]=1)[N:35](S(C1C=CC=CC=1)(=O)=O)[C:34]([C:48]([O:50]CC)=O)=[C:33]2[S:53](Cl)(=[O:55])=[O:54].Cl.CN.Cl.[CH3:61][S:62]([C:65]1[CH:72]=[CH:71][C:68]([CH2:69][NH2:70])=[CH:67][CH:66]=1)(=[O:64])=[O:63]>>[Br:29][C:30]1[CH:31]=[C:32]2[C:36](=[CH:37][CH:38]=1)[NH:35][C:34]([C:48]([NH2:7])=[O:50])=[C:33]2[S:53]([NH:70][CH2:69][C:68]1[CH:71]=[CH:72][C:65]([S:62]([CH3:61])(=[O:63])=[O:64])=[CH:66][CH:67]=1)(=[O:54])=[O:55]

Participants

5

Reactant 4

HCID 27292694-Methylsulfonylbenzylamine hydrochlorideHCID 6364545Methylamine hydrochlorideHCID 22401482ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylateHCID 86592455ethyl 3-(chlorosulfonyl)-5-bromo-1-(phenylsulfonyl)-1H-indole-2-carboxylate

Product 1

HCID 10074131HCID 10074131, compound

Procedure

Following the procedures described in Steps D and E of Example 1, replacing in Step D ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate with ethyl 5-bromo-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate, and methylamine hydrochloride with 4-(methylsulfonyl)benzylamine hydrochloride, the title compound was obtained. HRMS (ES) exact mass calculated for C17H17BrN3O5S2 (M+H+): 485.9788. Found 485.9784.

Sources & evidence

ORD record
ord-46c5d88bb17a4745ba0b78f5f9c3f090
Source dataset
uspto-grants-2011_08
Patent number
US08008295B2

Reaction notes

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