HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Chloroperbenzoic acid → Tert-butyl 3-[(4-chlorophenyl)sulfinyl]propylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | tert-Butyl 3-[(4-chlorophenyl)thio]propylcarbamate | HCID 85937154 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Tert-butyl 3-[(4-chlorophenyl)sulfinyl]propylcarbamate | HCID 91057009 | — |
Reaction Steps
The product from Example 70 Step B (70 mg) was stirred in 2 mL of dichloromethane with 3-chloroperoxybenzoic acid (MCPBA) (40 mg) for 1 hour at 0° C. An additional 5 mg of MCPBA was added and the reaction stirred 30 minutes more, then diluted with EtOAc and washed with saturated NaHCO3 and brine. The solution was dried over Na2SO4 and concentrated in vacuo to give the titled compound. ESI+ MS: 218 [MH-Boc]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008295B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-36a7385b049d4a0d9f7250baea14c19f |
| Source note | uspto-grants-2011_08 |