p-Anisoyl chloride → HCID 67373403, compound

HRID 1677009Notes

Reaction equation

HRID 1677009 reaction equation
Cl.[NH2:2][CH2:3][CH2:4][NH:5][S:6]([C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([Br:18])[CH:16]=2)[N:11]([S:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)(=[O:21])=[O:20])[C:10]=1[C:28]([O:30][CH2:31][CH3:32])=[O:29])(=[O:8])=[O:7].[CH3:33][O:34][C:35]1[CH:43]=[CH:42][C:38]([C:39](Cl)=[O:40])=[CH:37][CH:36]=1.C(N(CC)CC)C>ClCCl>[Br:18][C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[N:11]([S:19]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)(=[O:21])=[O:20])[C:10]([C:28]([O:30][CH2:31][CH3:32])=[O:29])=[C:9]2[S:6]([NH:5][CH2:4][CH2:3][NH:2][C:39](=[O:40])[C:38]1[CH:42]=[CH:43][C:35]([O:34][CH3:33])=[CH:36][CH:37]=1)(=[O:8])=[O:7]

Participants

5

Reactant 3

HCID 7477p-Anisoyl chlorideHCID 8471TriethylamineHCID 67373781HCID 67373781, compound

Product 1

HCID 67373403HCID 67373403, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from Example 89, Step A was combined with 1.1 equivalents of 4-methoxybenzoyl chloride and 3.0 equivalents of triethylamine in dichloromethane. The reaction was stirred for 1.5 hours at room temperature and the solvent was removed under a stream of nitrogen to give the titled compound. ESI+ MS: 664 [M+H]+.

Workup

  1. customthe solvent was removed under a stream of nitrogen

Sources & evidence

ORD record
ord-bc4602e96c2340fea6478fcd955d71ef
Source dataset
uspto-grants-2011_08
Patent number
US08008295B2

Reaction notes

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