HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Tetrahydro-2H-pyran-2-ylmethyl)amine → (+/-)-5-Iodo-3-{[(tetrahydro-2H-pyran-2-ylmethyl)amino]sulfonyl}-1H-indole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Tetrahydro-2H-pyran-2-ylmethyl)amine | HCID 97924 | — |
| Reactant | Methylamine hydrochloride | HCID 6364545 | — |
| Reactant | ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate | HCID 22401482 | — |
| Reactant | ethyl 5-iodo-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate | HCID 86601816 | — |
| Product | (+/-)-5-Iodo-3-{[(tetrahydro-2H-pyran-2-ylmethyl)amino]sulfonyl}-1H-indole-2-carboxamide | HCID 10004577 | — |
Reaction Steps
Following the procedures described in Steps D and E of Example 1, replacing in Step D ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate with ethyl 5-iodo-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate, and methylamine hydrochloride with (±)-1-tetrahydro-2H-pyran-2-ylmethanamine, the title compound was obtained. Proton NMR for the product was consistent with the titled compound. ESI+ MS: 463.95 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008295B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-2833be1b8b854a21bd79c9b4f7a40319 |
| Source note | uspto-grants-2011_08 |