Hydrochloric Acid → HCID 57541279, compound

HRID 1677034Notes

Reaction equation

HRID 1677034 reaction equation
C(OC([N:8]1[CH2:24][CH2:23][C:11]2[NH:12][C:13]3[C:14]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:15][CH:16]=[CH:17][C:18]=3[C:10]=2[CH2:9]1)=O)(C)(C)C.Cl>C(Cl)Cl.O1CCOCC1>[CH3:22][S:19]([C:14]1[C:13]2[NH:12][C:11]3[CH2:23][CH2:24][NH:8][CH2:9][C:10]=3[C:18]=2[CH:17]=[CH:16][CH:15]=1)(=[O:20])=[O:21]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57541287HCID 57541287, compound

Product 1

HCID 57541279HCID 57541279, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

6-methanesulfonyl-1,3,4,5-tetrahydro-pyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester (214 mg, 0.61 mmol) was dissolved in DCM (1 mL) and the 4M HCl in dioxane (1 mL) added. Evolution of gas commenced immediately and the reaction was stirred for 2.5 h when no further evolution was observed but a black solid had separated from the reaction.

Workup

  1. customa black solid had separated from the reaction

Sources & evidence

ORD record
ord-b614783e6af64f56bd41bc5fc23f29d7
Source dataset
uspto-grants-2011_08
Patent number
US08008279B2

Reaction notes

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