Potassium Carbonate → HCID 57541276, compound

Participants

Reaction Steps

Following on from Example 34, 4-(2-Chloroethyl)morpholine hydrochloride (90 mg, 0.48 mmol) was added to (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-hydroxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (131 mg, 0.32 mmol) and potassium carbonate (134 mg, 0.97 mmol) in DMF (5 ml) at 25° C. under air. The resulting solution was stirred at room temperature for 45 hours, to yield after purification a cream solid. (4.00 mg, 2.4%).

Provenance & Evidence